AroD

• Description: shikimate dehydrogenase
  
  

Gene name	aroD
Synonyms
Essential	no
Product	shikimate dehydrogenase
Function	biosynthesis of aromatic amino acids
Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp
MW, pI	30 kDa, 6.077
Gene length, protein length	840 bp, 280 aa
Immediate neighbours	yqeI, yqeH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU25660

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH (according to Swiss-Prot)

• Protein family: shikimate dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2HK8 (from Aquifex aeolicus, 42% identity, 61% similarity) PubMed

• UniProt: P54374

• KEGG entry: [2]

• E.C. number: 1.1.1.25

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

J Bergsma, K E Meihuizen, W Van Oeveren, W N Konings
Restoration of NADH oxidation with menaquinones and menaquinone analogues in membrane vesicles from the menaquinone-deficient Bacillus subtilis aroD.
Eur J Biochem: 1982, 125(3);651-7
[PubMed:6811271] [WorldCat.org] [DOI] (P p)