Difference between revisions of "TrpD"
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=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' ''[[trpE]]-[[trpD]]-[[trpC]]-[[trpF]]-[[trpB]]-[[trpA]]'' | + | * '''Operon:''' ''[[trpE]]-[[trpD]]-[[trpC]]-[[trpF]]-[[trpB]]-[[trpA]]-[[hisC]]-[[tyrA]]-[[aroE]]'' {{PubMed|3924737}} |
| − | * '''[[Sigma factor]]:''' [[SigA]] | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|6436812}} |
| − | * '''Regulation:''' induction by tryptophan ([[MtrB| TRAP]]) | + | * '''Regulation:''' |
| + | ** induction by tryptophan ([[MtrB| TRAP]]) {{PubMed|1551827}} | ||
| − | * '''Regulatory mechanism:''' [[MtrB| TRAP]]: binding to the mRNA in the presence of tryptophan, this results in transcription termination | + | * '''Regulatory mechanism:''' |
| + | ** [[MtrB| TRAP]]: binding to the mRNA in the presence of tryptophan, this results in transcription termination {{PubMed|8419914}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
Revision as of 19:34, 29 October 2009
- Description: anthranilate phosphoribosyltransferase
| Gene name | trpD |
| Synonyms | |
| Essential | no |
| Product | anthranilate phosphoribosyltransferase |
| Function | biosynthesis of tryptophan |
| Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp | |
| MW, pI | 35 kDa, 4.904 |
| Gene length, protein length | 1014 bp, 338 aa |
| Immediate neighbours | trpC, trpE |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU22670
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
- Protein family: 2-oxoacid dehydrogenase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: P03947
- KEGG entry: [3]
- E.C. number: 2.4.2.18
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
