Difference between revisions of "GroEL"

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=Expression and regulation=
 
=Expression and regulation=
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* '''Operon:''' ''[[groES]]-[[groEL]]'' {{PubMed|1350777}}
  
* '''Operon:'''  
+
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|1350776}}
  
* '''[[Sigma factor]]:'''
+
* '''Regulation:''' induced by heat shock ([[HrcA]]) {{PubMed|1350777,8576042}}
  
* '''Regulation:'''
+
* '''Regulatory mechanism:''' [[HrcA]]: transcription repression {{PubMed|8576042}}
 
 
* '''Regulatory mechanism:'''  
 
  
 
* '''Additional information:'''  
 
* '''Additional information:'''  
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=References=
 
=References=
  
<pubmed>9303302,1350777,12082092,,17726680 16493705 9303302, </pubmed>
+
<pubmed>9303302,1350777,12082092,,17726680 16493705 9303302,1350776 ,8576042 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 19:05, 23 August 2009

  • Description: chaperonin and co-repressor for HrcA

Gene name groEL
Synonyms
Essential yes PubMed
Product chaperonin, co-repressor for HrcA
Function protein folding and re-folding
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 57 kDa, 4.531
Gene length, protein length 1632 bp, 544 aa
Immediate neighbours groES, ydiM
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
GroEL context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU06030

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: acts as co-repressor for HrcA
  • Protein family: chaperonin (HSP60) family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated on ser/ thr/ tyr PubMed, PubMed
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism: HrcA: transcription repression PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Wolfgang Schumann, Bayreuth University, Germany Homepage

Your additional remarks

References