Difference between revisions of "SasA"
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* '''Regulation:''' Transcription is highly upregulated in response to lesions in late-acting teichoic acid synthesis genes, and therefore also in response to cell-wall-active compounds like bacitracin or vancomycin | * '''Regulation:''' Transcription is highly upregulated in response to lesions in late-acting teichoic acid synthesis genes, and therefore also in response to cell-wall-active compounds like bacitracin or vancomycin | ||
Revision as of 09:58, 10 July 2009
- Description: (p)ppGpp synthetase, small alarmone synthetase
| Gene name | ywaC |
| Synonyms | ipa-7d |
| Essential | no |
| Product | (p)ppGpp synthetase |
| Function | ppGpp synthesis independent from stringent response |
| MW, pI | 24 kDa, 6.217 |
| Gene length, protein length | 630 bp, 210 aa |
| Immediate neighbours | ywaD, menA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU38480
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s): YjbM
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- Swiss prot entry: P39583
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation: Transcription is highly upregulated in response to lesions in late-acting teichoic acid synthesis genes, and therefore also in response to cell-wall-active compounds like bacitracin or vancomycin
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Michael A D'Elia, Kathryn E Millar, Amit P Bhavsar, Ana M Tomljenovic, Bernd Hutter, Christoph Schaab, Gabriel Moreno-Hagelsieb, Eric D Brown
Probing teichoic acid genetics with bioactive molecules reveals new interactions among diverse processes in bacterial cell wall biogenesis.
Chem Biol: 2009, 16(5);548-56
[PubMed:19477419]
[WorldCat.org]
[DOI]
(I p)
Yousuke Natori, Kazumi Tagami, Kana Murakami, Sawako Yoshida, Osamu Tanigawa, Yoonsuh Moh, Kenta Masuda, Tetsuya Wada, Shota Suzuki, Hideaki Nanamiya, Yuzuru Tozawa, Fujio Kawamura
Transcription activity of individual rrn operons in Bacillus subtilis mutants deficient in (p)ppGpp synthetase genes, relA, yjbM, and ywaC.
J Bacteriol: 2009, 191(14);4555-61
[PubMed:19447912]
[WorldCat.org]
[DOI]
(I p)
Hideaki Nanamiya, Koji Kasai, Akira Nozawa, Choong-Soo Yun, Takakuni Narisawa, Kana Murakami, Yousuke Natori, Fujio Kawamura, Yuzuru Tozawa
Identification and functional analysis of novel (p)ppGpp synthetase genes in Bacillus subtilis.
Mol Microbiol: 2008, 67(2);291-304
[PubMed:18067544]
[WorldCat.org]
[DOI]
(P p)
