cimH

cimH
168

transporter for [metabolite|citrate] (proton symport)

locus
BSU_38770
Molecular weight
48.18 kDa
pI
6.55
Protein length
Gene length
function
[metabolite|citrate] uptake
product
transporter for [metabolite|citrate] (proton symport)
essential
no
synonyms
cimH, yxkJ

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3493 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,979,753 → 3,981,105
The protein
Catalyzed reaction/ biological activity
uptake of [metabolite|citrate] (symport with protons) under conditions of [metabolite|glutamate] deficiency [Pubmed|40490120,11566984]
Protein family
sodium:citrate (SCF) symporter family (together with [protein|F8F62635AA87E4E3A255D6F8FC621EF40954B520|maeN], according to UniProt)
Structure
[PDB|5X9R] (from Klebsiella pneumoniae, 34% identity) [pubmed|28566738]
[AF|P94363]
Paralogous protein(s)
[protein|F8F62635AA87E4E3A255D6F8FC621EF40954B520|maeN]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|FEC0EDE9663FE62B2A1A4FA5B16B41048DDD723B|cimH]
description
[Pubmed|21815947]
regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|10666464]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|10666464], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
additional information
the mRNA is substantially stabilized upon depletion of [gene|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [PubMed|21815947]
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[gene|FEC0EDE9663FE62B2A1A4FA5B16B41048DDD723B|cimH]

2025-06-11 07:37:48

ghost

85

149df7299eb9471922e4b283dde1bc3cbe518f2a

3A76ADF21BC7A81FAB283E3CBA9CB2E6E55D7F1E

Biological materials
Mutant
MGNA-B744 (yxkJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1743 NBRP B. subtilis, Japan]
BKE38770 (Δ[gene|FEC0EDE9663FE62B2A1A4FA5B16B41048DDD723B|cimH]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38770 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTGAAAAACCTCCCCTAT,  downstream forward: _UP4_TGATCCCCGCAAGCAAGTTC
BKK38770 (Δ[gene|FEC0EDE9663FE62B2A1A4FA5B16B41048DDD723B|cimH]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38770 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTGAAAAACCTCCCCTAT,  downstream forward: _UP4_TGATCCCCGCAAGCAAGTTC
GP4216 ([gene|FEC0EDE9663FE62B2A1A4FA5B16B41048DDD723B|cimH]::kan), available in Jörg Stülke's lab
References
Reviews
16339740
Original Publications
12525174,10666464,11566984,21815947,28566738,40490120

FEC0EDE9663FE62B2A1A4FA5B16B41048DDD723B

Page visits: 3245

Time of last update: 2025-06-11 06:18:39

Author of last update: Jstuelk