mdr

168

multidrug-efflux transporter (puromycin, nerfloxacin, tosufloxacin)

Locus: BSU_03070

Molecular weight: 46.65 kDa

Isoelectric point: 9.7

Protein length: 512 aa

Gene length: 1539 bp

Function: drug resistance

Product: multidrug-efflux transporter (puromycin, nerfloxacin, tosufloxacin)

Essential: no

Synonyms: mdr, ycgD, bmr3

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)

Gene

Coordinates: 332,441 → 333,979

The protein

Protein family

• major facilitator superfamily (according to UniProt)
• EmrB family (according to UniProt)

Structure

• 6OOM (PDB) (from E. coli, corresponds to aa 51 ... 412, 22% identity) PubMed
• P96712 (AlphaFold)

Localization

• cell membrane (according to UniProt)

Biological materials

Mutant

• BKE03070 (Δmdr::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTGTTCTACCTCCTCTT,  downstream forward: _UP4_TAACATAAAAAAAGCAGTAC
• BKK03070 (Δmdr::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTGTTCTACCTCCTCTT,  downstream forward: _UP4_TAACATAAAAAAAGCAGTAC

References

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