Difference between revisions of "FadH"
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− | * '''Description:''' | + | * '''Description:''' 2,4-dienoyl-CoA reductase <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ykuF'' | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ykuF'' | ||
|- | |- | ||
− | |style="background:#ABCDEF;" align="center"| '''Essential''' || | + | |style="background:#ABCDEF;" align="center"| '''Essential''' || no |
|- | |- | ||
− | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || 2,4-dienoyl-CoA reductase |
|- | |- | ||
− | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || fatty acid degradation |
+ | |- | ||
+ | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14060 fadH] | ||
+ | |- | ||
+ | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=fadH fadH]''' | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 6.495 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 6.495 | ||
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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 762 bp, 254 aa | |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 762 bp, 254 aa | ||
|- | |- | ||
− | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || | + | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ykuE]]'', ''[[fadG]]'' |
|- | |- | ||
− | |style="background:#FAF8CC;" align="center"|'''[http:// | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU14060 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU14060 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU14060 DNA_with_flanks] |
− | |||
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:ykuF_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:ykuF_context.gif]] | ||
+ | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
+ | |- | ||
+ | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=fadH_1478072_1478836_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:fadH_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14060]] | ||
|- | |- | ||
|} | |} | ||
__TOC__ | __TOC__ | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
+ | |||
+ | |||
+ | <br/><br/><br/><br/><br/><br/> | ||
+ | |||
+ | = [[Categories]] containing this gene/protein = | ||
+ | {{SubtiWiki category|[[utilization of lipids]]}} | ||
− | + | = This gene is a member of the following [[regulons]] = | |
+ | {{SubtiWiki regulon|[[FadR regulon]]}} | ||
=The gene= | =The gene= | ||
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=== Basic information === | === Basic information === | ||
− | * ''' | + | * '''Locus tag:''' BSU14060 |
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
=== Database entries === | === Database entries === | ||
+ | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU14060&redirect=T BSU14060] | ||
− | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ | + | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ykuFG.html] |
* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13290] | * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13290] | ||
=== Additional information=== | === Additional information=== | ||
+ | |||
+ | |||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
− | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' Trans-2,3-didehydroacyl-CoA + NADP<sup>+</sup> = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH (according to Swiss-Prot) |
− | * '''Protein family:''' | + | * '''Protein family:''' 2,4-dienoyl-CoA reductase subfamily (according to Swiss-Prot) |
* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
− | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
− | * '''Localization:''' | + | * '''[[Localization]]:''' |
=== Database entries === | === Database entries === | ||
+ | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU14060&redirect=T BSU14060] | ||
* '''Structure:''' | * '''Structure:''' | ||
− | * ''' | + | * '''UniProt:''' [http://www.uniprot.org/uniprot/O34717 O34717] |
− | * '''KEGG entry:''' | + | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU14060] |
− | * '''E.C. number:''' | + | * '''E.C. number:''' [http://www.expasy.org/enzyme/1.3.1.34 1.3.1.34] |
=== Additional information=== | === Additional information=== | ||
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=Expression and regulation= | =Expression and regulation= | ||
− | * '''Operon:''' | + | * '''Operon:''' ''[[fadH]]-[[fadG]]'' {{PubMed|17189250}} |
+ | |||
+ | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=fadH_1478072_1478836_1 fadH] {{PubMed|22383849}} | ||
* '''Sigma factor:''' | * '''Sigma factor:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
+ | ** induced in the presence of long-chain fatty acids ([[FadR]]) {{PubMed|17189250}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
+ | ** [[FadR]]: transcription repression {{PubMed|17189250}} | ||
− | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Line 118: | Line 144: | ||
=References= | =References= | ||
− | + | <pubmed>17189250,17919287</pubmed> | |
+ | |||
+ | [[Category:Protein-coding genes]] |
Latest revision as of 13:34, 2 April 2014
- Description: 2,4-dienoyl-CoA reductase
Gene name | fadH |
Synonyms | ykuF |
Essential | no |
Product | 2,4-dienoyl-CoA reductase |
Function | fatty acid degradation |
Gene expression levels in SubtiExpress: fadH | |
Metabolic function and regulation of this protein in SubtiPathways: fadH | |
MW, pI | 26 kDa, 6.495 |
Gene length, protein length | 762 bp, 254 aa |
Immediate neighbours | ykuE, fadG |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU14060
Phenotypes of a mutant
Database entries
- BsubCyc: BSU14060
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH (according to Swiss-Prot)
- Protein family: 2,4-dienoyl-CoA reductase subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- BsubCyc: BSU14060
- Structure:
- UniProt: O34717
- KEGG entry: [3]
- E.C. number: 1.3.1.34
Additional information
Expression and regulation
- Sigma factor:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References