gerE

168

transcriptional regulator (repressor or activator) of a subset of SigK-dependent late spore coat genes

Locus: BSU_28410

Molecular weight: 8.43 kDa

Isoelectric point: 9.64

Protein length: 74 aa

Gene length: 225 bp

Function: regulation of SigK-dependent gene expression

Product: transcriptional regulator (LuxR-FixJ family)

Essential: no

Synonyms: gerE

Genomic Context

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Categories containing this gene/protein

Information processing, Regulation of gene expression, Transcription factors and their control, Transcription factors/ other

Lifestyles, Sporulation, Germination, Additional germination proteins

List of homologs in different organisms, belongs to COG5905 (Galperin et al., 2021)

This gene is a member of the following regulons

SpoIIID regulon, SigK regulon, CitB regulon, GerE regulon

Gene

Coordinates: 2,904,727  2,904,951

Phenotypes of a mutant

unable to germinate efficiently PubMed

The protein

Protein family

LuxR-FixJ family of transcription regulators

Domains

HTH luxR-type domain (aa 5-70) (according to UniProt)

Structure

1FSE (PDB)
P11470 (AlphaFold)

Expression and Regulation

Operons

Genes: gerE

Description: PubMed

Regulation

expressed late during sporulation in the mother cell (SigK, SpoIIID) PubMed

Regulatory mechanism

SpoIIID: activation, PubMed, in spoIIID regulon
CitB: mRNA stability control, results in mRNA accumulation PubMed, in citB regulon

Sigma factors

SigK: sigma factor, PubMed, in sigK regulon

Biological materials

Mutant

BKE28410 (gerE::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAGTATTGTAACCCTCCTT,  downstream forward: _UP4_TAATCCTTGCCGGTATTCCT
BKK28410 (gerE::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAGTATTGTAACCCTCCTT,  downstream forward: _UP4_TAATCCTTGCCGGTATTCCT

Labs working on this gene/protein

Arthur Aronson, Purdue University, West Lafayette, USA homepage
Charles Moran, Emory University, NC, USA homepage

References

Reviews

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Original Publications

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