atpC

168

ATP synthase, part of the F1 complex (subunit epsilon)

Locus: BSU_36800

Molecular weight: 14.07 kDa

Isoelectric point: 5.26

Protein length: 132 aa

Gene length: 399 bp

Function: ATP synthesis

Product: ATP synthase (subunit epsilon)

Essential: no

Synonyms: atpC

Genomic Context

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List of homologs in different organisms, belongs to COG0355 (Galperin et al., 2021)

Gene

Coordinates: 3,781,069  3,781,467

The protein

Catalyzed reaction/ biological activity

• ATP synthesis see a video

Protein family

• ATPase epsilon chain family (single member, according to UniProt)

Structure

• 2E5Y (PDB) (from Bacillus sp., 71% identity) PubMed
• see here an overview on ATPase structure (PDB)
• P37812 (AlphaFold)

Effectors of protein activity

• ATPase activity is inhibited upon binding of Mg-ADP to AtpD PubMed

Localization

• cell membrane (Heterogeneous) PubMed
• peripheral via theF0 complex

Expression and Regulation

Operons

• Genes: atpI-atpB-atpE-atpF-atpH-atpA-atpG-atpD-atpC

  Description: PubMed

  Regulation

  • Rel dependent downregulation (Class I) during stringent response PubMed
  • the mRNA is processed between atpI and atpB by RNase Y, this requires the RicA-RicF-RicT complex PubMed

  Regulatory mechanism

  • stringent response: negative regulation, in stringent response

Biological materials

Mutant

• BKE36800 (atpC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCTTTTACCCTCCTAGG,  downstream forward: _UP4_TAAGAAAAAATCCTTCTCTT
• BKK36800 (atpC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCTTTTACCCTCCTAGG,  downstream forward: _UP4_TAAGAAAAAATCCTTCTCTT

References

Reviews

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Original Publications

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