dapF

168

diaminopimelate epimerase

Locus: BSU_32170

Molecular weight: 30.72 kDa

Isoelectric point: 4.51

Protein length: 284 aa

Gene length: 855 bp

Function: biosynthesis of lysine and peptidoglycan

Product: diaminopimelate epimerase

Essential: yes

E.C.: 5.1.1.7

Synonyms: dapF, yutL

Genomic Context

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List of homologs in different organisms, belongs to COG0253 (Galperin et al., 2021)

Gene

Coordinates: 3,306,040  3,306,894

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• LL-2,6-diaminoheptanedioate --> meso-2,6-diaminopimelate (according to UniProt)

Protein family

• diaminopimelate epimerase family (single member, according to UniProt)

Structure

• 2OTN (PDB) (from Bacillus anthracis str. ames, 62% identity, 75% similarity)
• O32114 (AlphaFold)

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: dapF-sufA

  Description: PubMed

Biological materials

Mutant

• MGNA-B574 (yutL::erm), available at the NBRP B. subtilis, Japan