comQ

168

prenylation of comX and surfactin expression (srfA)

Locus: BSU_31710

Molecular weight: 34.05 kDa

Isoelectric point: 4.89

Protein length: 299 aa

Gene length: 900 bp

Function: regulation of quorum sensing

Product: prenyltransferase

Essential: no

Synonyms: comQ

Genomic Context

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Categories containing this gene/protein

Information processing, Genetics, Genetic competence

Information processing, Protein synthesis, modification and degradation, Protein modification, Protein modification/ other

Information processing, Regulation of gene expression, Quorum sensing

Lifestyles, Exponential and early post-exponential lifestyles, Genetic competence

Groups of genes, Membrane proteins

List of homologs in different organisms, belongs to COG0142 (Galperin et al., 2021)

This gene is a member of the following regulons

SigA regulon

Gene

Coordinates: 3,256,008 → 3,256,907

Phenotypes of a mutant

the mutation suppresses the mucoid phenotype of ''motA or motB'' mutants due to loss of DegU phosphorylation and concomitant reduced expression of the ''capB-capC-capA-capE'' operon PubMed

The protein

Catalyzed reaction/ biological activity

prenylation of ComX on W-53 PubMed

Structure

P33690 (AlphaFold)

Localization

cell membrane (according to UniProt)

Expression and Regulation

Operons

Genes: comQ-comX-comP-comA-yuxO

Description: PubMed

Sigma factors

SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

BKE31710 (ΔcomQ::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTCTCCTTGATCCGGA,  downstream forward: _UP4_AGTTATACAAAGGGGGATAC
BKK31710 (ΔcomQ::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTCTCCTTGATCCGGA,  downstream forward: _UP4_AGTTATACAAAGGGGGATAC

References

Reviews

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Original Publications

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