menC

168

O-succinylbenzoate synthase

Locus: BSU_30780

Molecular weight: 41.47 kDa

Isoelectric point: 5.89

Protein length: 371 aa

Gene length: 1116 bp

Function: biosynthesis of menaquinone

Product: O-succinylbenzoate synthase

Essential: yes

E.C.: 4.2.1.113

Synonyms: menC, ytfD

Genomic Context

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List of homologs in different organisms, belongs to COG4948 (Galperin et al., 2021)

Gene

Coordinates: 3,146,238  3,147,353

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate --> 2-succinylbenzoate + H₂O (according to UniProt)

Protein family

• mandelate racemase/muconate lactonizing enzyme family (according to UniProt)

Structure

• 1WUE (PDB) (from Enterococcus faecalis, 45% identity) PubMed
• O34514 (AlphaFold)

Expression and Regulation

Operons

• Genes: menE-menC

  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon
  • SigB: sigma factor, PubMed, in sigB regulon

  Additional information

  • A ncRNA is predicted between 'mntA' and 'menC' PubMed

• Genes: menB-menE-menC

  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

  Additional information

  • A ncRNA is predicted between 'mntA' and 'menC' PubMed

• Genes: menF-menD-ytxM-menB-menE-menC

  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

  Additional information

  • A ncRNA is predicted between 'mntA' and 'menC' PubMed

References

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