groES

168

chaperonin, universally conserved protein

Locus: BSU_06020

Molecular weight: 10.04 kDa

Isoelectric point: 4.59

Protein length: 94 aa

Gene length: 285 bp

Function: protein folding and re-folding

Product: chaperonin

Essential: yes

Synonyms: groES, groS

Genomic Context

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List of homologs in different organisms, belongs to COG0234 (Galperin et al., 2021)

Gene

Coordinates: 649,903 650,187

Phenotypes of a mutant

• essential PubMed

The protein

Protein family

• groES chaperonin family (single member, according to UniProt)

Structure

• 1WE3 (PDB) (GroEL-GroES complex from Thermus thermophilus, 65% identity) PubMed
• P28599 (AlphaFold)

Modification

• phosphorylated on Ser-36 PubMed

Localization

• cytoplasm (according to Swiss-Prot)

Additional information

• Universally conserved protein
• belongs to the 100 most abundant proteins PubMed

Expression and Regulation

Operons

• Genes: groES-groEL

  Description: PubMed

  Regulation

  • induced by heat shock (HrcA) PubMed

  Regulatory mechanism

  • HrcA: repression, PubMed, in hrcA regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Labs working on this gene/protein

• Wolfgang Schumann, Bayreuth University, Germany Homepage

References

Reviews

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Original Publications

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