yvgN

168

glyoxal reductase, general stress protein

Locus: BSU_33400

Molecular weight: 31.51 kDa

Isoelectric point: 5.07

Protein length: 276 aa

Gene length: 831 bp

Function: unknown

Product: glyoxal reductase

Essential: no

E.C.: 1.1.1.283

Synonyms: yvgN, yvsB

Genomic Context

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Categories containing this gene/protein

Lifestyles, Coping with stress, General stress proteins (controlled by SigB)

Lifestyles, Coping with stress, Resistance against oxidative and electrophile stress

List of homologs in different organisms, belongs to COG0656 (Galperin et al., 2021)

Gene

Coordinates: 3,426,749  3,427,579

The protein

Catalyzed reaction/ biological activity

Lactaldehyde + NADP⁺ --> methylglyoxal + NADPH (according to UniProt)

Protein family

Aldo/keto reductase family (according to UniProt)

Cofactors

NADP⁺ PubMed

Structure

3B3E (PDB) PubMed
O32210 (AlphaFold)

Paralogous protein(s)

YtbE

Expression and Regulation

Operons

Genes: yvgN

Description: PubMed

Regulatory mechanism

SinR: repression, PubMed, in sinR regulon

Sigma factors

SigB: sigma factor, PubMed, in sigB regulon

Biological materials

Mutant

MGNA-B061 (yvgN::erm), available at the NBRP B. subtilis, Japan
BKE33400 (yvgN::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACTTGAACCTCCACCCTTT,  downstream forward: _UP4_TAATCAAAAAACTCCCCGTT
BKK33400 (yvgN::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACTTGAACCTCCACCCTTT,  downstream forward: _UP4_TAATCAAAAAACTCCCCGTT

References

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