mrpD

168

H⁺ transporter subunit of the Na⁺/H⁺ antiporter, multiple resistance and pH homeostasis

Locus: BSU_31630

Molecular weight: 53.21 kDa

Isoelectric point: 9.49

Protein length: 493 aa

Gene length: 1482 bp

Function: sodium export

Product: Na⁺/H⁺ antiporter subunit

Essential: yes

Synonyms: mrpD, yufD

Genomic Context

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List of homologs in different organisms, belongs to COG0651 (Galperin et al., 2021)

Gene

Coordinates: 3,249,761  3,251,242

Phenotypes of a mutant

• essential PubMed
• a ''mrpD'' mutant is viable at pH7.4 and sodium concentrations below 80 mM PubMed

The protein

Catalyzed reaction/ biological activity

• H+ transporter subunit of the Na+/H+ antiporter PubMed

Protein family

• CPA3 antiporters (TC 2.A.63) subunit D family (single member, according to UniProt)

Structure

• 4HE8 (PDB) (from Thermus thermophilus, 26% identity) PubMed
• O05229 (AlphaFold)

Localization

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: mrpA-mrpB-mrpC-mrpD-mrpE-mrpF-mrpG

  Description: PubMed

Biological materials

Mutant

• MGNA-A609 (yufD::erm), available at the NBRP B. subtilis, Japan

References

Reviews

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Original Publications

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