hemY

168

coproporphyrinogen oxidase

Locus: BSU_10140

Molecular weight: 51.04 kDa

Isoelectric point: 8.04

Protein length: 470 aa

Gene length: 1413 bp

Function: biosynthesis of heme

Product: coproporphyrinogen oxidase

Essential: no

E.C.: 1.3.3.4

Synonyms: hemY, hemG, cgoX

Genomic Context

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Categories containing this gene/protein

Metabolism, Additional metabolic pathways, Biosynthesis of cofactors, Biosynthesis of heme/ siroheme

Groups of genes, Membrane proteins

List of homologs in different organisms, belongs to COG1232 (Galperin et al., 2021)

Gene

Coordinates: 1,088,197  1,089,609

The protein

Catalyzed reaction/ biological activity

coproporphyrinogen --> coproporphyrin PubMed
3 O₂ + protoporphyrinogen IX --> 3 H₂O₂ + protoporphyrin IX (according to UniProt)

Protein family

Protoporphyrinogen oxidase family (single member, according to UniProt)

Cofactors

FAD PubMed

Structure

3I6D (PDB)
P32397 (AlphaFold)

Localization

cell membrane (peripheral) PubMed

Expression and Regulation

Operons

Genes: hemE-hemH-hemY

Description: PubMed

Biological materials

Mutant

BKE10140 (hemY::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GTCACTCATGTTCATCGCCT,  downstream forward: _UP4_TAAAACCTCCGCTTTATCGC
BKK10140 (hemY::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GTCACTCATGTTCATCGCCT,  downstream forward: _UP4_TAAAACCTCCGCTTTATCGC

References

Reviews

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Original Publications

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