yqjM

168

NADPH-dependent flavin oxidoreductase

Locus: BSU_23820

Molecular weight: 37.43 kDa

Isoelectric point: 5.14

Protein length: 338 aa

Gene length: 1017 bp

Function: reduction of double bonds of nonsaturated aldehydes

Product: NADPH-dependent flavin oxidoreductase

Essential: no

Synonyms: yqjM

Genomic Context

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List of homologs in different organisms, belongs to COG1902 (Galperin et al., 2021)

Gene

Coordinates: 2,475,843 → 2,476,859

The protein

Catalyzed reaction/ biological activity

• A + H⁺ + NADPH --> AH₂ + NADP⁺ (according to UniProt)

Protein family

• NADH:flavin oxidoreductase/NADH oxidase family (with YqiG, according to UniProt)

Cofactors

• FMN PubMed

Structure

• 1Z41 (PDB) (oxidized form),  1Z48 (PDB) (reduced form) PubMed
• P54550 (AlphaFold)

Paralogous protein(s)

• YqiG

Expression and Regulation

Operons

• Genes: yqjM

  Description: PubMed

  Regulation

  • induced in the presence of H₂O₂ PubMed

Biological materials

Mutant

• BKE23820 (ΔyqjM::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCTTTCGCCTCCCGTA,  downstream forward: _UP4_TAATGCCCATAAGAGATATC
• BKK23820 (ΔyqjM::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCTTTCGCCTCCCGTA,  downstream forward: _UP4_TAATGCCCATAAGAGATATC

References

Reviews

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Original Publications

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