pgsA

168

phosphatidylglycerophosphate synthase

Locus: BSU_16920

Molecular weight: 21.16 kDa

Isoelectric point: 5.16

Protein length: 193 aa

Gene length: 582 bp

Function: biosynthesis of phospholipids

Product: phosphatidylglycerophosphate synthase

Essential: yes

E.C.: 2.7.8.5

Synonyms: pgsA, ymfN

Genomic Context

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List of homologs in different organisms, belongs to COG0558 (Galperin et al., 2021)

Gene

Coordinates: 1,762,623  1,763,204

Phenotypes of a mutant

• some point mutations resulting in reduced PgsA activity lead to daptomycin resistance PubMedessential PubMed
• depletion leads to hypersensitivity to sorbic acid stress PubMed

The protein

Catalyzed reaction/ biological activity

• CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate --> 1,2-diacyl-sn-glycero-3-phospho-(1ʼ-sn-glycero-3ʼ-phosphate) + CMP + H⁺ (according to UniProt)

Protein family

• CDP-alcohol phosphatidyltransferase class-I family (with PssA, according to UniProt)

Structure

• P46322 (AlphaFold)

Localization

• cell membrane at the septum PubMed

Biological materials

Mutant

• 1A815 ( pgsA::erm), PubMed, available at BGSC

References

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