fadM
168
fatty acid degradation, similar to proline dehydrogenase
Locus
BSU_32850
Molecular weight
34.30 kDa
Isoelectric point
9.38
Function
fatty acid degradation
Product
unknown
Essential
no
Synonyms
fadM, yusM
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0506 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,372,740 → 3,373,648
The protein
Catalyzed reaction/ biological activity
quinone + L-proline --> (S)-1-pyrroline-5-carboxylate + quinol + H+ (according to UniProt)
Protein family
proline dehydrogenase family (with PutB, according to UniProt)
FAD (according to UniProt)
Structure
4H6Q (PDB) (from Deinococcus radiodurans, 48% identity) PubMed
Paralogous protein(s)
Expression and Regulation
Operons
Biological materials
Mutant
MGNA-A598 (yusM::erm), available at the NBRP B. subtilis, Japan
References
Crystal structures and kinetics of monofunctional proline dehydrogenase provide insight into substrate recognition and conformational changes associated with flavin reduction and product release.
Biochemistry. 2012 Dec 18; 51(50):10099-108. doi:10.1021/bi301312f. PMID:23151026
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
The Journal of biological chemistry. 2007 Feb 23; 282(8):5180-94. . PMID:17189250
Cannibalism by sporulating bacteria.
Science (New York, N.Y.). 2003 Jul 25; 301(5632):510-3. . PMID:12817086
Page visits: 4484
Time of last update: 2025-07-14 09:26:12
Author of last update: Melvin.boenninger