fadM

fadM
168

fatty acid degradation, similar to proline dehydrogenase

Locus
BSU_32850
Molecular weight
34.30 kDa
Isoelectric point
9.38
Protein length
Gene length
Function
fatty acid degradation
Product
unknown
Essential
no
Synonyms
fadM, yusM

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0506 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,372,740 → 3,373,648
The protein
Catalyzed reaction/ biological activity
quinone + L-proline --> (S)-1-pyrroline-5-carboxylate + quinol + H+ (according to UniProt)
Protein family
proline dehydrogenase family (with PutB, according to UniProt)
FAD (according to UniProt)
Structure
4H6Q (PDB) (from Deinococcus radiodurans, 48% identity) PubMed
Paralogous protein(s)
Expression and Regulation
Operons
Description
Regulation
''fadM'': induced by long-chain fatty acids (FadR) PubMed
Regulatory mechanism
FadR: repression, PubMed, in fadR regulon
SdpR: activation, PubMed, in sdpR regulon
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fadMfadE

2025-07-10 21:09:05

ghost

122

9bfdfb93c4077983c0e3142e433ac74ae81a5d62

8E61A92B7F4E3CA1E4373E8AFCCD07598481ACA4

Biological materials
Mutant
MGNA-A598 (yusM::erm), available at the NBRP B. subtilis, Japan
BKE32850 (ΔfadM::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATCCGACTCCCTCCCGCCG,  downstream forward: _UP4_TGAAAGCAGCCGTGGGAAGC
BKK32850 (ΔfadM::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATCCGACTCCCTCCCGCCG,  downstream forward: _UP4_TGAAAGCAGCCGTGGGAAGC
References
Luo M, Arentson BW, Srivastava D, Becker DF, Tanner JJ Crystal structures and kinetics of monofunctional proline dehydrogenase provide insight into substrate recognition and conformational changes associated with flavin reduction and product release. Biochemistry. 2012 Dec 18; 51(50):10099-108. doi:10.1021/bi301312f. PMID:23151026
Matsuoka H, Hirooka K, Fujita Y Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation. The Journal of biological chemistry. 2007 Feb 23; 282(8):5180-94. . PMID:17189250
González-Pastor JE, Hobbs EC, Losick R Cannibalism by sporulating bacteria. Science (New York, N.Y.). 2003 Jul 25; 301(5632):510-3. . PMID:12817086

F8C51A86268DC6B2152B139D2D0B25CC3D69A5D5

Page visits: 4484

Time of last update: 2025-07-14 09:26:12

Author of last update: Melvin.boenninger