Difference between revisions of "Main Page"

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<big>'''Upcoming events:'''</big>  
 
<big>'''Upcoming events:'''</big>  
* The BACELL meeting 2015, organized by [[Leendert Hamoen]] will take place from April 14 to 15 in Amsterdam, The Netherlands. [http://www.sysbio.se/Bacell2015/ Website], [mailto:L.W.Hamoen@uva.nl Contact]
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* The [http://www.bacillus-2017.de/ 19th International Conference on Bacilli & Gram-Positive Bacteria] organized by [[Jörg Stülke]] will take place from June 11 to June 15, 2017, in Berlin, Germany. [http://www.bacillus-2017.de/ Conference website]
* The International Conference on Metabolic Engineering, organized by [[Ivan Mijakovic]] and [[Leendert Hamoen]] will take place from April 16 to 17 in Amsterdam, The Netherlands. [http://www.sysbio.se/MEB/ Website], [mailto:L.W.Hamoen@uva.nl Contact]
 
* The [http://www.grampositiveconference.org/  8th International Conference on Gram-positive Microorganisms] (18th International Conference on Bacilli) in Montecatini Terme, organized by [[Marta Perego]], [[Jim Hoch]], and [[Hendrik Szurmant]] will take place from June 21 to 25. [http://www.grampositiveconference.org/registration.html Conference website]
 
 
* [[Past conferences]]
 
* [[Past conferences]]
  
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<big>'''Now online: A new description of ''Subti''Wiki and its acompanying modules in the [http://nar.oxfordjournals.org/content/40/D1/D1278.full.pdf+html 2014 Database issue of Nucleic Acids Research]'''</big>  
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<big>'''Now online: A new description of ''Subti''Wiki and its acompanying modules in the [https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkv1006 2016 Database issue of Nucleic Acids Research]'''</big>  
 
<pubmed> 24178028 </pubmed>
 
<pubmed> 24178028 </pubmed>
  
 
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<br/>
<big>'''Paper of the month: February 2015'''</big>  
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<big>'''Paper of the month: August 2015'''</big>  
* To proliferate efficiently, cells must co-ordinate [[cell division]] with [[DNA condensation/ segregation|chromosome segregation]]. In ''B. subtilis'', the nucleoid occlusion protein [[Noc]] binds to specific DNA sequences scattered around the chromosome and helps to protect genomic integrity by coupling the initiation of division to the progression of chromosome replication and segregation. However, how it inhibits division has remained unclear. Now, [http://www.ncbi.nlm.nih.gov/pubmed/25568309 Adams et al.] from the lab of [[Jeff Errington]] demonstrate that [[Noc]] associates with the cell membrane via an N-terminal amphipathic helix. Importantly, the membrane-binding affinity of this helix is weak and requires the assembly of nucleoprotein complexes, thus establishing a mechanism for DNA-dependent activation of [[Noc]]. Furthermore, division inhibition by [[Noc]] requires recruitment of [[Noc]] binding site DNA to the cell membrane and is dependent on its ability to bind DNA and membrane simultaneously. The results suggest a simple model in which the formation of large membrane-associated nucleoprotein complexes physically occludes assembly of the [[divisome|division machinery]].
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* The cells in a biofilm experience very different conditions: While the inner cells are well protected from any harm from the environment, they have on the other hand only poor access to nutrients. For the cells on the edge of the biofilm, it is just the other way round. Now, [http://www.ncbi.nlm.nih.gov/pubmed/26200335 Liu et al.] from the lab of [[Gürol M. Süel]] have discovered oscillation in the [[biofilm formation|growth of the biofilm]]. These oscillations serve to provide the inner cells with access to nutrients. These oscillations are caused by metabolic co-dependence between cells in the biofilm periphery and interior that is driven by [[glutamate metabolism|glutamate consumption and ammonium production]], respectively.
* '''Relevant ''Subti''Wiki pages:''' [[Noc]], [[Jeff Errington]], [[cell division]], [[DNA condensation/ segregation|chromosome segregation]]
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* '''Relevant ''Subti''Wiki pages:''' [[Gürol M. Süel]], [[glutamate metabolism|glutamate consumption and ammonium production]], [[biofilm formation]]
<pubmed>25568309</pubmed>
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* see [http://microbepost.org/2015/08/05/conflict-and-co-operation-in-bacterial-communities/ a blog presenting this paper]
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<pubmed>26200335</pubmed>
 
* [[Previous papers of the month]]
 
* [[Previous papers of the month]]
  
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|width="300"|<big>'''Additional pages'''</big>
 
|width="300"|<big>'''Additional pages'''</big>
 
|- style="height:20px"  
 
|- style="height:20px"  
| ''[[spo0A]]'' || '''[http://subtiwiki.uni-goettingen.de/subtipathways/start.php ''Subti''Pathways]'''  
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| ''[[spo0A]]'' || '''[[template]]'''  
 
|-
 
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| ''[[glnA]]'' ||  '''[http://subtiwiki.uni-goettingen.de/interact/ SubtInteract]'''
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| ''[[glnA]]'' ||  '''[[the people behind SubtiWiki|the people behind ''Subti''Wiki]]'''
 
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| ''[[rny]]'' ||  '''[http://subtiwiki.uni-goettingen.de/apps/expression/ SubtiExpress]'''
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| ''[[rny]]'' ||  '''[[labs working on Bacillus|labs working on ''Bacillus'']]'''
 
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| ''[[psdA]]'' || '''[[Regulons]]'''  
 
| ''[[psdA]]'' || '''[[Regulons]]'''  
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| ''[[mreC]]'' || '''[[labs working on Bacillus|labs working on ''Bacillus'']]'''
 
| ''[[mreC]]'' || '''[[labs working on Bacillus|labs working on ''Bacillus'']]'''
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| ''[[ccpA]]'' || '''[[the people behind SubtiWiki|the people behind ''Subti''Wiki]]'''
 
|-
 
| ''[[sr1]]'' || '''[[template]]'''
 
 
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Latest revision as of 10:15, 22 February 2017

Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!

Start page small.png
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Contact: General Microbiology, University of Göttingen, send mail


Upcoming events:


New: Subtiwiki is now on Facebook - please give it a +1!



Now online: A new description of SubtiWiki and its acompanying modules in the 2016 Database issue of Nucleic Acids Research



Paper of the month: August 2015

Jintao Liu, Arthur Prindle, Jacqueline Humphries, Marçal Gabalda-Sagarra, Munehiro Asally, Dong-yeon D Lee, San Ly, Jordi Garcia-Ojalvo, Gürol M Süel
Metabolic co-dependence gives rise to collective oscillations within biofilms.
Nature: 2015, 523(7562);550-4
[PubMed:26200335] [WorldCat.org] [DOI] (I p)


New procedure for account creation:

  • Due to massive spam attacks, we had to change our policy for the creation of accounts. If you want to create an account, just send me a mail. We will create the account for you as quickly as possible, then you can change your password. This does not affect existing accounts, which remain active.
  • Please remember that all members of the Bacillus community are invited to create accounts and to contribute to SubtiWiki!



News in SubtiWiki:

  • August 2014: The first mobile application for SubtiWiki is now available for users of Android phones: Go for SubtiWiki in Google Play! IPhone users, please be patient! You will be served next! Click here to install!
  • April 2013: SubtiWiki uses a new, faster Mediawiki platform! The times for page access are significantly reduced. Enjoy!
  • March 2013: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
  • October 2012: the essential genes have been categorized
  • September 2012: 300 mutant strains available at the BGSC were added to the corresponding gene pages
  • August 2012: SubtiExpress, the new compagnon of SubtiWiki devoted to gene expression is online! Try it out!
  • April 2012: Links for expression data under 104 different conditions (based on Nicolas et al., 2012) have been added to the expression section of the individual gene pages
  • April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
  • December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways



Genes (examples) Additional pages
spo0A template
glnA the people behind SubtiWiki
rny labs working on Bacillus
psdA Regulons
pckA methods
dnaA metabolism
rnpA categories
sigB genome-wide analyses
ptkA list of plasmids
mreC labs working on Bacillus


Publications describing SubtiWiki and SubtiPathways: