Difference between revisions of "Condensin"
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| − | == Condensin is a conserved protein complex that binds the origin region of the DNA. It is required for segregation of the origin regions after DNA replication. == | + | == Condensin is a conserved protein complex that binds the origin region of the DNA. It is required for segregation of the origin regions after DNA replication. Condensin is a central modulator of chromosome superstructure in all domains of life.== |
== Mutants lacking condensin components are viable as long as they grow slowly (i.e. on minimal medium), but the components are essential for rapid growth (on LB). == | == Mutants lacking condensin components are viable as long as they grow slowly (i.e. on minimal medium), but the components are essential for rapid growth (on LB). == | ||
| − | == Localization of the condensin complex depends on [[ | + | == Localization of the condensin complex depends on [[ParB]]. The condensin ([[Smc]])2-[[ScpA]]-[[ScpB]] complex is loaded by [SW|ParB] to ''parS'' centromeric sites adjacent to the replication origin, travels then from the origin to the terminus at rates >50 kb per minute [Pubmed|28154080,24440393,23475963]== |
== The condensin complex: [[Smc]]<sub>2</sub>-[[ScpA]]-[[ScpB]] == | == The condensin complex: [[Smc]]<sub>2</sub>-[[ScpA]]-[[ScpB]] == | ||
| + | |||
| + | ==Back to [[protein-protein interactions]]== | ||
== Important publications == | == Important publications == | ||
| − | <pubmed>24440399,24440393 24829297 24118085 25071173 </pubmed> | + | <pubmed>24440399,24440393 24829297 24118085 25071173 25557547 23218009 22855829 25951515 26253537 26295962,26706151,26725510,28154080,31201090,31175837 31548377 ,32250245</pubmed> |
Latest revision as of 13:27, 7 April 2020
Contents
- 1 Condensin is a conserved protein complex that binds the origin region of the DNA. It is required for segregation of the origin regions after DNA replication. Condensin is a central modulator of chromosome superstructure in all domains of life.
- 2 Mutants lacking condensin components are viable as long as they grow slowly (i.e. on minimal medium), but the components are essential for rapid growth (on LB).
- 3 Localization of the condensin complex depends on ParB. The condensin (Smc)2-ScpA-ScpB complex is loaded by [SW|ParB] to parS centromeric sites adjacent to the replication origin, travels then from the origin to the terminus at rates >50 kb per minute [Pubmed|28154080,24440393,23475963]
- 4 The condensin complex: Smc2-ScpA-ScpB
- 5 Back to protein-protein interactions
- 6 Important publications
Condensin is a conserved protein complex that binds the origin region of the DNA. It is required for segregation of the origin regions after DNA replication. Condensin is a central modulator of chromosome superstructure in all domains of life.
Mutants lacking condensin components are viable as long as they grow slowly (i.e. on minimal medium), but the components are essential for rapid growth (on LB).
Localization of the condensin complex depends on ParB. The condensin (Smc)2-ScpA-ScpB complex is loaded by [SW|ParB] to parS centromeric sites adjacent to the replication origin, travels then from the origin to the terminus at rates >50 kb per minute [Pubmed|28154080,24440393,23475963]
The condensin complex: Smc2-ScpA-ScpB
Back to protein-protein interactions
Important publications
