valS

168

valyl-tRNA synthetase

Locus: BSU_28090

Molecular weight: 101.55 kDa

Isoelectric point: 4.87

Protein length: 880 aa

Gene length: 2643 bp

Function: translation

Product: valyl-tRNA synthetase

Essential: yes

E.C.: 6.1.1.9

Synonyms: valS

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG0525 (Galperin et al., 2021)

Gene

Coordinates: 2,866,664 2,869,306

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + L-valine + tRNA(Val) --> AMP + diphosphate + L-valyl-tRNA(Val) (according to UniProt)

Protein family

• Class-I aminoacyl-tRNA synthetase family (according to UniProt)

Structure

• 1IYW (PDB) (from Thermus thermophilus, 41% identity, 60% similarity) PubMed
• Q05873 (AlphaFold)

Additional information

• belongs to the 100 most abundant proteins PubMed

Expression and Regulation

Operons

• Genes: valS-folC

  Description: PubMed

  Regulation

  • induced by valine limitation (T-box) PubMed
  • the T-box RNA is degraded by RNase Y PubMed

  Regulatory mechanism

  • T-box: RNA switch, via riboswitch, in T-box

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

References

Reviews

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Original Publications

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