Difference between revisions of "MgsR"
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| − | * '''Description:''' transcriptional regulator of a subset of the [[SigB]] general stress regulon <br/><br/> | + | * '''Description:''' transcriptional regulator of a subset of the [[SigB]] general stress regulon, required for protection against oxidative stress <br/><br/> |
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24770 mgsR] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24770 mgsR] | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=MgsR MgsR] |
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 9.28 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 9.28 | ||
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
{{SubtiWiki category|[[transcription factors and their control]]}}, | {{SubtiWiki category|[[transcription factors and their control]]}}, | ||
| − | {{SubtiWiki category|[[general stress proteins (controlled by SigB)]]}} | + | {{SubtiWiki category|[[general stress proteins (controlled by SigB)]]}}, |
| + | {{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}} | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24770&redirect=T BSU24770] | ||
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yqgZ.html] | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yqgZ.html] | ||
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24770&redirect=T BSU24770] | ||
* '''Structure:''' | * '''Structure:''' | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mgsR_2564026_2564406_-1 mgsR] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mgsR_2564026_2564406_-1 mgsR] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' [[SigB]] {{PubMed|18643936}} | + | * '''[[Sigma factor]]:''' [[SigB]] {{PubMed|18643936}} |
* '''Regulation:''' | * '''Regulation:''' | ||
| Line 142: | Line 145: | ||
=References= | =References= | ||
| − | + | <pubmed>18643936, 12107147 15805528 18643936,22812682 22582280</pubmed> | |
| − | <pubmed>18643936, 12107147 15805528 18643936, </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Latest revision as of 14:13, 2 April 2014
- Description: transcriptional regulator of a subset of the SigB general stress regulon, required for protection against oxidative stress
| Gene name | mgsR |
| Synonyms | yqgZ |
| Essential | no |
| Product | transcriptional regulator |
| Function | controls a subset of general stress genes |
| Gene expression levels in SubtiExpress: mgsR | |
| Interactions involving this protein in SubtInteract: MgsR | |
| MW, pI | 14 kDa, 9.28 |
| Gene length, protein length | 378 bp, 126 aa |
| Immediate neighbours | trnSL-Gln1, yqgY |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
transcription factors and their control, general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU24770
Phenotypes of a mutant
Database entries
- BsubCyc: BSU24770
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: exerts a positive or negative effect on the expression of 53 or 18 stress genes, respectively PubMed
- Protein family: arsC family (according to Swiss-Prot) Arsenate Reductase (ArsC) family, Spx subfamily
- Paralogous protein(s): Spx
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- BsubCyc: BSU24770
- Structure:
- UniProt: P54503
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: mgsR PubMed
- Regulatory mechanism:
- MgsR: transcription activation PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Alexander Reder, Dierk-Christoph Pöther, Ulf Gerth, Michael Hecker
The modulator of the general stress response, MgsR, of Bacillus subtilis is subject to multiple and complex control mechanisms.
Environ Microbiol: 2012, 14(10);2838-50
[PubMed:22812682]
[WorldCat.org]
[DOI]
(I p)
Alexander Reder, Dirk Höper, Ulf Gerth, Michael Hecker
Contributions of individual σB-dependent general stress genes to oxidative stress resistance of Bacillus subtilis.
J Bacteriol: 2012, 194(14);3601-10
[PubMed:22582280]
[WorldCat.org]
[DOI]
(I p)
Alexander Reder, Dirk Höper, Christin Weinberg, Ulf Gerth, Martin Fraunholz, Michael Hecker
The Spx paralogue MgsR (YqgZ) controls a subregulon within the general stress response of Bacillus subtilis.
Mol Microbiol: 2008, 69(5);1104-20
[PubMed:18643936]
[WorldCat.org]
[DOI]
(I p)
Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528]
[WorldCat.org]
[DOI]
(P p)
Ulrike Mäder, Georg Homuth, Christian Scharf, Knut Büttner, Rüdiger Bode, Michael Hecker
Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.
J Bacteriol: 2002, 184(15);4288-95
[PubMed:12107147]
[WorldCat.org]
[DOI]
(P p)
