hemY

168

coproporphyrinogen oxidase

Locus: BSU_10140

Molecular weight: 51.04 kDa

Isoelectric point: 8.04

Protein length: 470 aa

Gene length: 1413 bp

Function: biosynthesis of heme

Product: coproporphyrinogen oxidase

Essential: no

E.C.: 1.3.3.4

Synonyms: hemY, hemG, cgoX

Genomic Context

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List of homologs in different organisms, belongs to COG1232 (Galperin et al., 2021)

Gene

Coordinates: 1,088,197  1,089,609

The protein

Catalyzed reaction/ biological activity

• coproporphyrinogen --> coproporphyrin PubMed
• 3 O₂ + protoporphyrinogen IX --> 3 H₂O₂ + protoporphyrin IX (according to UniProt)

Protein family

• Protoporphyrinogen oxidase family (single member, according to UniProt)

Cofactors

• FAD PubMed

Structure

• 3I6D (PDB)
• P32397 (AlphaFold)

Localization

• cell membrane (peripheral) PubMed

Expression and Regulation

Operons

• Genes: hemE-hemH-hemY

  Description: PubMed

Biological materials

Mutant

• BKE10140 (hemY::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GTCACTCATGTTCATCGCCT,  downstream forward: _UP4_TAAAACCTCCGCTTTATCGC
• BKK10140 (hemY::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GTCACTCATGTTCATCGCCT,  downstream forward: _UP4_TAAAACCTCCGCTTTATCGC

References

Reviews

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Original Publications

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