spo0M

168

sporulation-control gene

Locus: BSU_08760

Molecular weight: 29.56 kDa

Isoelectric point: 4.28

Protein length: 258 aa

Gene length: 777 bp

Function: sporulation

Product: unknown

Essential: no

Synonyms: spo0M, ygaI

Genomic Context

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List of homologs in different organisms, belongs to COG4326 (Galperin et al., 2021)

Gene

Coordinates: 953,373  954,149

Phenotypes of a mutant

• Blocked at stage zero of sporulation and is susceptible to lysis during vegetative growth PubMed

The protein

Protein family

• spo0M family (single member, according to UniProt)

Structure

• 5CL2 (PDB) PubMed
• P71088 (AlphaFold)

Effectors of protein activity

• the protein is degraded by the FtsH metalloprotease PubMed

Localization

• scattered distribution pattern in cells, appearing near the cell poles and the septum region PubMed

Expression and Regulation

Operons

• Genes: spo0M

  Description: PubMed

  Sigma factors

  • SigH: sigma factor, PubMed, in sigH regulon
  • SigW: sigma factor, PubMed, in sigW regulon

  Additional information

  • the protein is degraded by the FtsH metalloprotease PubMed

Biological materials

Mutant

• BKE08760 (spo0M::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTAGATCTTCCCCTTT,  downstream forward: _UP4_TAAGTATAAAAAGGAGCCGA
• BKK08760 (spo0M::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTAGATCTTCCCCTTT,  downstream forward: _UP4_TAAGTATAAAAAGGAGCCGA

References

Reviews

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Original Publications

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