phrE

168

response regulator aspartate phosphatase (RapE) regulator, control of the phosphorelay

Locus: BSU_25840

Molecular weight: 4.72 kDa

Isoelectric point: 8.86

Protein length: 44 aa

Gene length: 135 bp

Function: control of sporulation initiation

Product: phosphatase (RapE) regulator

Essential: no

E.C.: null

Synonyms: phrE

Genomic Context

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List of homologs in different organisms

Gene

Coordinates: 2,660,330  2,660,464

The protein

Protein family

• phr family (according to UniProt)

Structure

• O32025 (AlphaFold)

Expression and Regulation

Operons

• Genes: phrE

  Description: PubMed

  Regulation

  • repressed by glucose (10-fold) (CcpA) PubMed

  Regulatory mechanism

  • CcpA: repression, in ccpA regulon
  • CodY: repression, PubMed, in codY regulon
  • AbrB: repression, PubMed, in abrB regulon
  • ComA: activation, in comA regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon
  • SigH: sigma factor, PubMed, in sigH regulon

• Genes: rapE-phrE

  Description: PubMed

  Regulation

  • repressed by glucose (10-fold) (CcpA) PubMed

  Regulatory mechanism

  • CodY: repression, PubMed, in codY regulon
  • ComA: activation, in comA regulon

Biological materials

Mutant

• BKE25840 (phrE::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AACGGCGGATAAACTGATAA,  downstream forward: _UP4_TAATTCGATAAACAACATTA
• BKK25840 (phrE::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AACGGCGGATAAACTGATAA,  downstream forward: _UP4_TAATTCGATAAACAACATTA

References

Reviews

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Original Publications

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