DEAD-box RNA helicases

Parent categories	3. Information processing 3.2. RNA synthesis and degradation
Neighbouring categories	3.2.1. Transcription 3.2.2. RNA chaperones 3.2.3. DEAD-box RNA helicases 3.2.4. RNases
Related categories	RNA chaperones
Overview on the categories (Excel file) All genes and their categories (Excel file)

Labs working on DEAD-box RNA helicases

• Dagmar Klostermeier
• Jörg Stülke
• Mohamed Marahiel

DEAD-box RNA helicases in B. subtilis

• CshA
• CshB
• DeaD
• YfmL

Strain GP1063 deleted for all four DEAD-box RNA helicases is available in Jörg Stülke's lab (cshA::aphA3 cshB::cat deaD::tet yfmL::ermC). The individual mutants are available as well. PubMed

Important original publications

Martin Lehnik-Habrink, Leonie Rempeters, Ákos T Kovács, Christoph Wrede, Claudia Baierlein, Heike Krebber, Oscar P Kuipers, Jörg Stülke
DEAD-Box RNA helicases in Bacillus subtilis have multiple functions and act independently from each other.
J Bacteriol: 2013, 195(3);534-44
[PubMed:23175651] [WorldCat.org] [DOI] (I p)

N Kyle Tanner, Olivier Cordin, Josette Banroques, Monique Doère, Patrick Linder
The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis.
Mol Cell: 2003, 11(1);127-38
[PubMed:12535527] [WorldCat.org] [DOI] (P p)

Key reviews

Vanessa Khemici, Patrick Linder
RNA helicases in bacteria.
Curr Opin Microbiol: 2016, 30;58-66
[PubMed:26808656] [WorldCat.org] [DOI] (I p)

Peter Redder, Stéphane Hausmann, Vanessa Khemici, Haleh Yasrebi, Patrick Linder
Bacterial versatility requires DEAD-box RNA helicases.
FEMS Microbiol Rev: 2015, 39(3);392-412
[PubMed:25907111] [WorldCat.org] [DOI] (I p)

Markus G Rudolph, Dagmar Klostermeier
When core competence is not enough: functional interplay of the DEAD-box helicase core with ancillary domains and auxiliary factors in RNA binding and unwinding.
Biol Chem: 2015, 396(8);849-65
[PubMed:25720120] [WorldCat.org] [DOI] (I p)

Patrick Linder, Frances Fuller-Pace
Happy birthday: 25 years of DEAD-box proteins.
Methods Mol Biol: 2015, 1259;17-33
[PubMed:25579577] [WorldCat.org] [DOI] (I p)

Steven W Hardwick, Ben F Luisi
Rarely at rest: RNA helicases and their busy contributions to RNA degradation, regulation and quality control.
RNA Biol: 2013, 10(1);56-70
[PubMed:23064154] [WorldCat.org] [DOI] (I p)

Patrick Linder, Eckhard Jankowsky
From unwinding to clamping - the DEAD box RNA helicase family.
Nat Rev Mol Cell Biol: 2011, 12(8);505-16
[PubMed:21779027] [WorldCat.org] [DOI] (I e)

Franck Pandiani, Stéphanie Chamot, Julien Brillard, Frédéric Carlin, Christophe Nguyen-the, Véronique Broussolle
Role of the five RNA helicases in the adaptive response of Bacillus cereus ATCC 14579 cells to temperature, pH, and oxidative stresses.
Appl Environ Microbiol: 2011, 77(16);5604-9
[PubMed:21705526] [WorldCat.org] [DOI] (I p)

Varinia López-Ramírez, Luis D Alcaraz, Gabriel Moreno-Hagelsieb, Gabriela Olmedo-Álvarez
Phylogenetic distribution and evolutionary history of bacterial DEAD-Box proteins.
J Mol Evol: 2011, 72(4);413-31
[PubMed:21437710] [WorldCat.org] [DOI] (I p)

Xinliang Zhao, Chaitanya Jain
DEAD-box proteins from Escherichia coli exhibit multiple ATP-independent activities.
J Bacteriol: 2011, 193(9);2236-41
[PubMed:21378185] [WorldCat.org] [DOI] (I p)

Franck Pandiani, Julien Brillard, Isabelle Bornard, Caroline Michaud, Stéphanie Chamot, Christophe Nguyen-the, Véronique Broussolle
Differential involvement of the five RNA helicases in adaptation of Bacillus cereus ATCC 14579 to low growth temperatures.
Appl Environ Microbiol: 2010, 76(19);6692-7
[PubMed:20709848] [WorldCat.org] [DOI] (I p)

Eric A Gustafson, Gary M Wessel
DEAD-box helicases: posttranslational regulation and function.
Biochem Biophys Res Commun: 2010, 395(1);1-6
[PubMed:20206133] [WorldCat.org] [DOI] (I p)

Manuel Hilbert, Anne R Karow, Dagmar Klostermeier
The mechanism of ATP-dependent RNA unwinding by DEAD box proteins.
Biol Chem: 2009, 390(12);1237-50
[PubMed:19747077] [WorldCat.org] [DOI] (I p)

Patrick Linder
Dead-box proteins: a family affair--active and passive players in RNP-remodeling.
Nucleic Acids Res: 2006, 34(15);4168-80
[PubMed:16936318] [WorldCat.org] [DOI] (I p)

Frances V Fuller-Pace
DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation.
Nucleic Acids Res: 2006, 34(15);4206-15
[PubMed:16935882] [WorldCat.org] [DOI] (I p)

Olivier Cordin, Josette Banroques, N Kyle Tanner, Patrick Linder
The DEAD-box protein family of RNA helicases.
Gene: 2006, 367;17-37
[PubMed:16337753] [WorldCat.org] [DOI] (P p)

Sanda Rocak, Patrick Linder
DEAD-box proteins: the driving forces behind RNA metabolism.
Nat Rev Mol Cell Biol: 2004, 5(3);232-41
[PubMed:14991003] [WorldCat.org] [DOI] (P p)

N Kyle Tanner
The newly identified Q motif of DEAD box helicases is involved in adenine recognition.
Cell Cycle: 2003, 2(1);18-9
[PubMed:12695678] [WorldCat.org] [DOI] (P p)

Jon R Lorsch
RNA chaperones exist and DEAD box proteins get a life.
Cell: 2002, 109(7);797-800
[PubMed:12110176] [WorldCat.org] [DOI] (P p)

External links

• The RNA helicase database