uppS
168
undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis
Locus
BSU_16530
Molecular weight
29.63 kDa
Isoelectric point
5.41
Function
cell wall biosynthesis
Product
undecaprenyl pyrophosphate synthetase
Essential
yes
E.C.
2.5.1.31
Synonyms
uppS, yluA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0020 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,721,214 1,721,996
Phenotypes of a mutant
The protein
Catalyzed reaction/ biological activity
catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate
Protein family
UPP synthetase family (single member, according to UniProt)
Structure
1X09 (PDB) (the protein from E. coli, 49% identity, 77% similarity) PubMed
Expression and Regulation
Biological materials
Mutant
MGNA-B080 (yluA::erm), available at the NBRP B. subtilis, Japan
References
Bacillus subtilis MurJ and Amj Lipid II flippases are not essential for growth.Journal of bacteriology. 2025 Apr 4; :e0007825. PMID: 40183557
Comprehensive double-mutant analysis of the Bacillus subtilis envelope using double-CRISPRi.bioRxiv : the preprint server for biology. 2024 Aug 16; . PMID: 39185233
Protein complexes in cells by AI-assisted structural proteomics.Molecular systems biology. 2023 Feb 23; :e11544. PMID: 36815589
Magnesium Modulates Bacillus subtilis Cell Division Frequency.Journal of bacteriology. 2022 Dec 14; :e0037522. PMID: 36515540
Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria.Journal of medicinal chemistry. 2021 Sep 2; . PMID: 34473495
Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase.
ChemMedChem. 2016 Oct 19; 11(20):2311-2319. doi:10.1002/cmdc.201600342. PMID:27578312
Bacterial cell morphogenesis does not require a preexisting template structure.
Current biology : CB. 2014 Apr 14; 24(8):863-7. doi:10.1016/j.cub.2014.02.053. pii:S0960-9822(14)00251-6. PMID:24704074
Coregulation of Terpenoid Pathway Genes and Prediction of Isoprene Production in Bacillus subtilis Using Transcriptomics.
PloS one. 2013; 8(6):e66104. doi:10.1371/journal.pone.0066104. PMID:23840410
Reducing the Level of Undecaprenyl Pyrophosphate Synthase Has Complex Effects on Susceptibility to Cell Wall Antibiotics.
Antimicrobial agents and chemotherapy. 2013 Sep; 57(9):4267-4275. doi:10.1128/AAC.00794-13. PMID:23796923
Undecaprenyl pyrophosphate involvement in susceptibility of Bacillus subtilis to rare earth elements.
Journal of bacteriology. 2012 Oct; 194(20):5632-7. . PMID:22904278
Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis.
The Journal of biological chemistry. 2005 May 27; 280(21):20762-74. . PMID:15788389
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Time of last update: 2025-06-19 21:44:54
Author of last update: Jstuelk