glyQ

168

glycyl-tRNA synthetase (alpha subunit)

Locus: BSU_25270

Molecular weight: 33.83 kDa

Isoelectric point: 4.8

Protein length: 295 aa

Gene length: 888 bp

Function: translation

Product: glycyl-tRNA synthetase (alpha subunit)

Essential: yes

E.C.: 6.1.1.14

Synonyms: glyQ, yqfJ

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG0752 (Galperin et al., 2021)

Gene

Coordinates: 2,607,762 2,608,649

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + glycine + tRNA^Gly --> AMP + diphosphate + glycyl-tRNA^Gly (according to UniProt)

Protein family

• Class-II aminoacyl-tRNA synthetase family (according to UniProt)

Structure

• 1J5W (PDB) (from Thermotoga maritima, 55% identity, 72% similarity)
• 6POM (PDB) (the glyQ riboswitch in complex with tRNA-Gly) PubMed
• P54380 (AlphaFold)

Localization

• cytoplasm (according to Swiss-Prot)

Additional information

• belongs to the 100 most abundant proteins PubMed

Expression and Regulation

Operons

• Genes: glyQ-glyS

  Description: PubMed

  Regulation

  • induced by glycine limitation (T-box) PubMed

  Regulatory mechanism

  • T-box: RNA switch, PubMed, in T-box

References

Reviews

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Original Publications

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