cmk

168

cytidylate kinase (CMP, dCMP)

Locus: BSU_22890

Molecular weight: 24.95 kDa

Isoelectric point: 5

Protein length: 224 aa

Gene length: 675 bp

Function: synthesis of CTP and dCTP

Product: cytidylate kinase (CMP, dCMP)

Essential: yes

E.C.: 2.7.4.14

Synonyms: cmk, jofC, ypfC

Genomic Context

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Categories containing this gene/protein

Metabolism, Nucleotide metabolism, Biosynthesis/ acquisition of nucleotides, Biosynthesis/ acquisition of pyrimidine nucleotides

Groups of genes, Essential genes

List of homologs in different organisms, belongs to COG0283 (Galperin et al., 2021)

Gene

Coordinates: 2,396,045  2,396,719

Phenotypes of a mutant

essential PubMed

The protein

Catalyzed reaction/ biological activity

ATP + CMP --> ADP + CDP (according to UniProt)
ATP + dCMP --> ADP + dCDP (according to UniProt)

Protein family

cytidylate kinase family (single member, according to UniProt)

Structure

1CKE (PDB) (from Escherichia coli, 38% identity, 54% similarity) PubMed
P38493 (AlphaFold)

Expression and Regulation

Operons

Genes: cmk-rpsA

Description: PubMed

Genes: cmk-rpsA-fni

Description: PubMed

Genes: motI-ypfB-cmk-rpsA-fni

Description: PubMed

Genes: motI-ypfB-cmk-rpsA

Description: PubMed

References

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