ebrB

168

multidrug efflux transporter

Locus: BSU_17290

Molecular weight: 12.19 kDa

Isoelectric point: 6.93

Protein length: 117 aa

Gene length: 354 bp

Function: multidrug resistance

Product: multidrug efflux transporter

Essential: no

Synonyms: ebrB

Genomic Context

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List of homologs in different organisms, belongs to COG2076 (Galperin et al., 2021)

Gene

Coordinates: 1,864,691  1,865,044

The protein

Protein family

• paired small multidrug resistance  protein family (PSMR family) PubMed
• drug/metabolite transporter (DMT) superfamily (according to UniProt)
• Small multidrug resistance (SMR) (TC 2.A.7.1) family (according to UniProt)

Structure

• 3B5D (PDB) (EmrE from E. coli, 39% identity) PubMed

Paralogous protein(s)

• EbrA

Localization

• cell membrane PubMed

Expression and Regulation

Operons

• Genes: ebrA-ebrB

  Description: PubMed

Biological materials

Mutant

• MGNA-B077 (ebrB::erm), available at the NBRP B. subtilis, Japan
• BKE17290 (ebrB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATCCTCTCATCTTCATCA,  downstream forward: _UP4_GCCTGTGAGTGACCGTCTGT
• BKK17290 (ebrB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATCCTCTCATCTTCATCA,  downstream forward: _UP4_GCCTGTGAGTGACCGTCTGT

References

Reviews

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Original Publications

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