ctaE

168

cytochrome-c oxidase (caa₃) (subunit III)

Locus: BSU_14910

Molecular weight: 23.12 kDa

Isoelectric point: 7.41

Protein length: 207 aa

Gene length: 624 bp

Function: respiration

Product: cytochrome-c oxidase (subunit III)

Essential: no

E.C.: 1.9.3.1

Synonyms: ctaE

Genomic Context

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List of homologs in different organisms, belongs to COG1845 (Galperin et al., 2021)

Gene

Coordinates: 1,563,437  1,564,060

The protein

Catalyzed reaction/ biological activity

• 4 [Fe(II)cytochrome c] + 4 H⁺ + O₂ --> 4 [Fe(III)cytochrome c] + 2 H₂O (according to UniProt)

Protein family

• cytochrome c oxidase subunit 3 family (with QoxC, according to UniProt)

Structure

• 1FFT (PDB) (ubichinol oxidase from E. coli, 43% identity) PubMed
• P24012 (AlphaFold)

Localization

• cell membrane PubMed

Expression and Regulation

Operons

• Genes: ctaB-ctaC-ctaD-ctaE-ctaF-ctaG

  Description: PubMed

  Regulation

  • expressed under anaerobic conditions (ResD) PubMed

  Regulatory mechanism

  • ResD: activation, PubMed, in resD regulon
  • Abh: repression, synergistic repression with AbrB, in abh regulon
  • CcpA: repression, in ccpA regulon
  • AbrB: repression, synergistic repression with Abh, in abrB regulon

Biological materials

Mutant

• BKE14910 (ctaE::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GGTGAATTTTTCTTGAACTT,  downstream forward: _UP4_TTAATGGGGATGGTGGGATA
• BKK14910 (ctaE::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GGTGAATTTTTCTTGAACTT,  downstream forward: _UP4_TTAATGGGGATGGTGGGATA

References

Reviews

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Original Publications

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