phrA

168

response regulator aspartate phosphatase (RapA) inhibitor, control of the phosphorelay

Locus: BSU_12440

Molecular weight: 4.66 kDa

Isoelectric point: 10.23

Protein length: 44 aa

Gene length: 135 bp

Function: control of sporulation initiation

Product: phosphatase (RapA) inhibitor

Essential: no

Synonyms: phrA, gsiAB

Genomic Context

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List of homologs in different organisms

Gene

Coordinates: 1,316,995 → 1,317,129

The protein

Protein family

• phr family (according to UniProt)

Structure

• Q00829 (AlphaFold)

Expression and Regulation

Operons

• Genes: rapA-phrA

  Description: PubMed

  Regulation

  • expressed at high cell density (ComA) PubMed

  Regulatory mechanism

  • Spo0A: repression, PubMed, in spo0A regulon
  • ComA: activation, (ComA) PubMed, in comA regulon
  • CodY: repression, PubMed, in codY regulon
  • CcpA: repression, PubMed, in ccpA regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

• BKE12440 (ΔphrA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATTTAGATTTCATATAAACA,  downstream forward: _UP4_TGATGCATAAAAAAAGACCC
• BKK12440 (ΔphrA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATTTAGATTTCATATAAACA,  downstream forward: _UP4_TGATGCATAAAAAAAGACCC

References

Reviews

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Original Publications

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