ytpA

ytpA
168

phospholipase (annotated as a bacilysocin synthase)

Locus
BSU_30510
Molecular weight
29.42 kDa
Isoelectric point
6.77
Protein length
Gene length
Function
lipid degradation
Product
phospholipase
Essential
no
Synonyms
ytpA

Genomic Context

List of homologs in different organisms, belongs to COG2267 (Galperin et al., 2021)

This gene is a member of the following regulons

SigM regulon

Gene
Coordinates
3,122,662  3,123,441
The protein
Catalyzed reaction/ biological activity
cleaves fatty acids from the 2 position of phosphatidylglycerol PubMed
Protein family
AB hydrolase superfamily (according to UniProt)
3 AB hydrolase-1 domains (aa 37-52, aa 84-97, aa 198-212) (according to InterPro)
Structure
3HJU (PDB) (human monoglyceride lipase, 30% identity) PubMed
Expression and Regulation
Operons
Genes
Description
Regulation
expressed under conditions of salt stress (SigM) PubMed
induced by cell wall-inhibiting drugs, such as bacitracin and cefuroxime (SigM) PubMed
Sigma factors
SigM: sigma factor, PubMed, in sigM regulon
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ytpAytpB

2025-07-20 22:23:29

Jstuelk

97

41A293118D974BA8F373EA72D3616B1F31A4B6E6

6E9DEAC29839E036AE05C9AB94BA1EAB44ED7718

Biological materials
Mutant
MGNA-A128 (ytpA::erm), available at the NBRP B. subtilis, Japan
BKE30510 (ytpA::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATGATCTTCACCTCATACG,  downstream forward: _UP4_TGAACTAGTAGGGGGTGCAT
BKK30510 (ytpA::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATGATCTTCACCTCATACG,  downstream forward: _UP4_TGAACTAGTAGGGGGTGCAT
References
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Time of last update: 2025-07-28 08:30:17

Author of last update: Jstuelk