dppC

168

dipeptide ABC transporter (permease)

Locus: BSU_12940

Molecular weight: 35.65 kDa

Isoelectric point: 9.81

Protein length: 320 aa

Gene length: 963 bp

Function: uptake of dipeptides

Product: dipeptide ABC transporter (permease)

Essential: no

Synonyms: dppC, dciAC

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG1173 (Galperin et al., 2021)

Gene

Coordinates: 1,362,174 → 1,363,136

The protein

Protein family

• Binding-protein-dependent transport system permease family (according to UniProt)
• OppBC subfamily (according to UniProt)

Domains

• ABC transmembrane type-1 domain (aa 117-307) (according to UniProt)

Structure

• P26904 (AlphaFold)

Paralogous protein(s)

• AppC, OppC

Localization

• cell membrane PubMed

Expression and Regulation

Operons

• Genes: dppA-dppB-dppC-dppD-dppE

  Description: PubMed

  Regulation

  • repressed by glucose (2.9-fold) PubMed

  Regulatory mechanism

  • CodY: repression, PubMed, in codY regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

• Genes: dppA-dppB-dppC-dppD-dppE-ykfA-ykfB-ykfC-ykfD

  Description: PubMed

  Regulatory mechanism

  • CodY: repression, PubMed, in codY regulon

Biological materials

Mutant

• BKE12940 (ΔdppC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTGTACAGGGAGATTCACAC,  downstream forward: _UP4_GACCCTAAGCTGAGGAGGTA
• BKK12940 (ΔdppC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTGTACAGGGAGATTCACAC,  downstream forward: _UP4_GACCCTAAGCTGAGGAGGTA

References

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