csbC

168

general stress protein, similar to sugar-H⁺ symporter, required for protection against paraquat stress

Locus: BSU_39810

Molecular weight: 49.97 kDa

Isoelectric point: 9.94

Protein length: 461 aa

Gene length: 1386 bp

Function: protection against paraquat stress

Product: putative sugar-H⁺ symporter

Essential: no

Synonyms: csbC, yxcC

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)

Gene

Coordinates: 4,088,002  4,089,387

The protein

Protein family

• major facilitator superfamily (according to UniProt)
• Sugar transporter (TC 2.A.1.1) family (according to UniProt)

Domains

• contains 12 trans-membrane domains PubMed

Structure

• 4LDS (PDB) (from Staphylococcus epidermidis, 54% identity) PubMed
• P46333 (AlphaFold)

Paralogous protein(s)

• CsbC, IolT, AraE, YwtG, YfiG, YncC

Localization

• homogeneously distributed in the cell membrane PubMed

Expression and Regulation

Operons

• Genes: csbC

  Regulation

  • induced by stress (sigB) PubMed

  Sigma factors

  • SigB: sigma factor, PubMed, in sigB regulon

Biological materials

Mutant

• MGNA-B695 (yxcC::erm), available at the NBRP B. subtilis, Japan
• BKE39810 (csbC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACAAATGTCTCCTCCTCAG,  downstream forward: _UP4_TAAAAAAAGGAATCGTCTCC
• BKK39810 (csbC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACAAATGTCTCCTCCTCAG,  downstream forward: _UP4_TAAAAAAAGGAATCGTCTCC

References

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