purL
168
phosphoribosylformylglycinamidine synthase
Locus
BSU_06480
Molecular weight
80.10 kDa
Isoelectric point
4.55
Function
purine biosynthesis
Product
phosphoribosylformylglycinamidine synthase
Essential
no
E.C.
6.3.5.3
Synonyms
purL
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0046 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
703,237 705,465
The protein
Catalyzed reaction/ biological activity
ATP + H2O + L-glutamine + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide --> 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + ADP + H+ + L-glutamate + phosphate(according to UniProt)
H2O + L-glutamine --> L-glutamate + NH4+ (according to UniProt)
Protein family
FGAMS family (single member, according to UniProt)
Structure
3D54 (PDB) (from Thermotoga maritima, 39% identity, 58% similarity) PubMed
cytoplasm (according to UniProt)
membrane associated PubMed
Additional information
subject to Clp-dependent proteolysis upon glucose starvation PubMed
belongs to the 100 most abundant proteins PubMed
Expression and Regulation
Operons
Description
Regulation
expression activated by glucose (4.4 fold) PubMed
Regulatory mechanism
Sigma factors
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Biological materials
Mutant
References
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Time of last update: 2025-08-18 19:31:36
Author of last update: Melvin.boenninger