yoeA

168

multidrug resistance protein, major exporter of plipastatin

Locus: BSU_18370

Molecular weight: 51.12 kDa

Isoelectric point: 10

Protein length: 463 aa

Gene length: 1392 bp

Function: export of plipastatin

Product: major exporter of plipastatin

Essential: no

Synonyms: yoeA

Genomic Context

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List of homologs in different organisms, belongs to COG0534 (Galperin et al., 2021)

Gene

Coordinates: 2,000,960  2,002,351

Phenotypes of a mutant

• growth is inhibited in the presence of plipastatin PubMed

The protein

Catalyzed reaction/ biological activity

• major exporter of plipastatin PubMed

Protein family

• MOP exporter family
• multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family (according to UniProt)

Structure

• 3VVO (PDB) (MATE multidrug exporter from Pyrococcus furiosus, 25% identity) PubMed
• O34474 (AlphaFold)

Localization

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: yoeA

  Description: PubMed

  Additional information

  • An ncRNA is predicted for 'yoeA' PubMed

Biological materials

Mutant

• BKE18370 (yoeA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATTAAAGGACTCCTTTA,  downstream forward: _UP4_TAGCCTCCGAATCACACCGT
• BKK18370 (yoeA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATTAAAGGACTCCTTTA,  downstream forward: _UP4_TAGCCTCCGAATCACACCGT

References

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