dxs

168

1-deoxyxylulose-5-phosphate synthase, first step in the MEP pathway of isoprenoid biosynthesis

Locus: BSU_24270

Molecular weight: 69.38 kDa

Isoelectric point: 6

Protein length: 633 aa

Gene length: 1902 bp

Function: biosynthesis of thiamine, MEP pathway of isoprenoid biosynthesis

Product: 1-deoxyxylulose-5-phosphate synthase

Essential: yes

E.C.: 2.2.1.7

Synonyms: dxs, yqiE

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

Metabolism, Lipid metabolism, Biosynthesis of lipids, Biosynthesis of isoprenoids

Metabolism, Additional metabolic pathways, Biosynthesis of cofactors, Biosynthesis/ acquisition of thiamine

Groups of genes, Essential genes

List of homologs in different organisms, belongs to COG1154 (Galperin et al., 2021)

This gene is a member of the following regulons

Stringent response

Gene

Coordinates: 2,523,713 → 2,525,614

Phenotypes of a mutant

essential PubMed

The protein

Catalyzed reaction/ biological activity

D-glyceraldehyde 3-phosphate + H⁺ + pyruvate --> 1-deoxy-D-xylulose 5-phosphate + CO₂ (according to UniProt)

Protein family

transketolase family (with Tkt, according to UniProt)

Cofactors

TPP PubMed

Structure

2O1S (PDB) (from E. coli, 44% identity, 62% similarity) PubMed
P54523 (AlphaFold)

Expression and Regulation

Operons

Genes: dxs-tlyA-ahrC-recN

Description: PubMed

Regulation

Rel dependent downregulation (Class I) during stringent response PubMed

Regulatory mechanism

stringent response: negative regulation, PubMed, in stringent response

References

Reviews

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Original Publications

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