dppA

168

D-alanyl-aminopeptidase

Locus: BSU_12920

Molecular weight: 30.09 kDa

Isoelectric point: 5.19

Protein length: 274 aa

Gene length: 825 bp

Function: degradation of cell wall peptides

Product: D-alanyl-aminopeptidase

Essential: no

E.C.: null

Synonyms: dppA, dciAA

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG2362 (Galperin et al., 2021)

Gene

Coordinates: 1,360,401  1,361,225

The protein

Protein family

• peptidase M55 family (single member, according to UniProt)

Structure

• 1HI9 (PDB)
• P26902 (AlphaFold)

Modification

• phosphorylated on ser/ thr/ tyr PubMed

Expression and Regulation

Operons

• Genes: dppA-dppB-dppC-dppD-dppE

  Description: PubMed

  Regulation

  • repressed by glucose (2.9-fold) PubMed

  Regulatory mechanism

  • CodY: repression, PubMed, in codY regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

• Genes: dppA-dppB-dppC-dppD-dppE-ykfA-ykfB-ykfC-ykfD

  Description: PubMed

  Regulatory mechanism

  • CodY: repression, PubMed, in codY regulon

Biological materials

Mutant

• BKE12920 (dppA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAACGCTCCTCCTTTTTT,  downstream forward: _UP4_TTCTGCTAAAGGGGTGTTTT
• BKK12920 (dppA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAACGCTCCTCCTTTTTT,  downstream forward: _UP4_TTCTGCTAAAGGGGTGTTTT

References

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