glcR

168

transcriptional repressor (DeoR family) of the glcR-phoC operon

Locus: BSU_36300

Molecular weight: 28.67 kDa

Isoelectric point: 5.69

Protein length: 258 aa

Gene length: 777 bp

Function: unknown

Product: transcriptional repressor (DeoR family)

Essential: no

Synonyms: glcR, ywpI

Genomic Context

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List of homologs in different organisms, belongs to COG1349 (Galperin et al., 2021)

Gene

Coordinates: 3,739,206  3,739,982

The protein

Protein family

• DeoR family of transcription factors

Domains

• HTH deoR-type domain (aa 3-58) (according to UniProt)

Structure

• P94591 (AlphaFold)

Additional information

• Mutant forms of GlcR act as "super-repressors" of'' ptsG'' expression PubMed

Expression and Regulation

Operons

• Genes: glcR-phoC

  Description: PubMed

  Regulation

  • induced by phosphosugar stress PubMed

  Regulatory mechanism

  • GlcR: repression, PubMed, in glcR regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

• MGNA-A530 (ywpI::erm), available at the NBRP B. subtilis, Japan
• BKE36300 (glcR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACGCCCTCATTCCTTTTCT,  downstream forward: _UP4_GATGAAGGAAAGGACTGACA
• BKK36300 (glcR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACGCCCTCATTCCTTTTCT,  downstream forward: _UP4_GATGAAGGAAAGGACTGACA

References

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