appC

168

oligopeptide ABC transporter (permease)

Locus: BSU_11400

Molecular weight: 33.27 kDa

Isoelectric point: 9.78

Protein length: 303 aa

Gene length: 912 bp

Function: uptake of oligopeptides

Product: oligopeptide ABC transporter (permease)

Essential: no

Synonyms: appC

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG1173 (Galperin et al., 2021)

Gene

Coordinates: 1,216,210  1,217,121

The protein

Protein family

• Binding-protein-dependent transport system permease family (according to UniProt)
• OppBC subfamily (according to UniProt)

Domains

• ABC transmembrane type-1 domain (aa 90-299) (according to UniProt)

Structure

• P42063 (AlphaFold)

Paralogous protein(s)

• OppC, DppC

Localization

• cell membrane PubMed

Expression and Regulation

Operons

• Genes: appD-appF-appA/1-appA/2-appB-appC

  Description: PubMed

  Regulation

  • repressed by CodY PubMed

  Regulatory mechanism

  • TnrA: activation, PubMed, in tnrA regulon
  • CodY: repression, PubMed PubMed, in codY regulon
  • ScoC: repression, PubMed, in scoC regulon

Biological materials

Mutant

• GP2100 (D(''appD-appF-appA/2-appB-appC)::spc''), available in Jörg Stülke's lab
• BKE11400 (appC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTCTGTTTCCCTCCTTT,  downstream forward: _UP4_TAAAAATGAATATCATATCT
• BKK11400 (appC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTCTGTTTCCCTCCTTT,  downstream forward: _UP4_TAAAAATGAATATCATATCT

References

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