murE

168

UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase

Locus: BSU_15180

Molecular weight: 54.16 kDa

Isoelectric point: 5.56

Protein length: 494 aa

Gene length: 1485 bp

Function: peptidoglycan precursor biosynthesis

Product: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase

Essential: yes

E.C.: 6.3.2.13

Synonyms: murE

Genomic Context

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List of homologs in different organisms, belongs to COG0769 (Galperin et al., 2021)

Gene

Coordinates: 1,586,330 → 1,587,814

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + meso-2,6-diaminopimelate + UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate --> ADP + H⁺ + phosphate + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-diaminopimelate (according to UniProt)

Protein family

• MurCDEF family (according to UniProt)

Structure

• 2WTZ (PDB) (from Mycobacterium tuberculosis, 35% identity, 50% similarity) PubMed
• Q03523 (AlphaFold)

Localization

• forms banded patterns along the length of the cell, this pattern formation depends on MreB PubMed

Expression and Regulation

Operons

• Genes: murE-mraY-murD-spoVE-murG-murB-divIB-ylxW-ylxX-sbp

  Description: PubMed

  Regulation

  • expressed during vegatative growth PubMed

  Regulatory mechanism

  • stringent response: negative regulation, in stringent response
  • SpoIIID: repression, PubMed, in spoIIID regulon

  Sigma factors

  • SigE: sigma factor, PubMed, in sigE regulon

References

Reviews

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Original Publications

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