Difference between revisions of "OhrA"
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| − | * '''Description:''' | + | * '''Description:''' peroxiredoxin , protects the cell against organic peroxides <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || peroxiredoxin |
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || organic peroxide resistance | |style="background:#ABCDEF;" align="center"|'''Function''' || organic peroxide resistance | ||
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13140 ohrA] | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 5.061 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 5.061 | ||
| Line 20: | Line 22: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[proA]]'', ''[[ohrR]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[proA]]'', ''[[ohrR]]'' | ||
|- | |- | ||
| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13140 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13140 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13140 DNA_with_flanks] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:yklA_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:yklA_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
| + | |- | ||
| + | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ohrA_1380978_1381403_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:ohrA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13140]] | ||
|- | |- | ||
|} | |} | ||
__TOC__ | __TOC__ | ||
| + | <br/><br/><br/><br/> | ||
| + | <br/><br/><br/><br/> | ||
| + | <br/><br/><br/><br/> | ||
| + | <br/><br/><br/><br/> | ||
| + | <br/><br/><br/><br/> | ||
| + | |||
<br/><br/> | <br/><br/> | ||
| + | |||
| + | = [[Categories]] containing this gene/protein = | ||
| + | {{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}} | ||
| + | |||
| + | = This gene is a member of the following [[regulons]] = | ||
| + | {{SubtiWiki regulon|[[OhrR regulon]]}} | ||
=The gene= | =The gene= | ||
| Line 40: | Line 56: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU13140&redirect=T BSU13140] | ||
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yklA.html] | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yklA.html] | ||
| Line 46: | Line 63: | ||
=== Additional information=== | === Additional information=== | ||
| + | |||
| + | |||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
| − | * '''Localization:''' | + | * '''[[Localization]]:''' |
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU13140&redirect=T BSU13140] | ||
* '''Structure:''' | * '''Structure:''' | ||
| − | * ''' | + | * '''UniProt:''' [http://www.uniprot.org/uniprot/O34762 O34762] |
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU13140] | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU13140] | ||
| Line 88: | Line 108: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' | + | * '''Operon:''' ''[[ohrA]]'' {{PubMed|9696771}} |
| + | |||
| + | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ohrA_1380978_1381403_1 ohrA] {{PubMed|22383849}} | ||
| − | * ''' | + | * '''Sigma factor:''' [[SigA]] {{PubMed|9696771}} |
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** induced by organic peroxides ([[OhrR]]) {{PubMed|11418552}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[OhrR]]: transcription repression {{PubMed|11418552}} | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
| + | ** number of protein molecules per cell (minimal medium with glucose and ammonium): 205 {{PubMed|24696501}} | ||
=Biological materials = | =Biological materials = | ||
| Line 119: | Line 144: | ||
<pubmed>16209951,12486061,11418552,9696771,, </pubmed> | <pubmed>16209951,12486061,11418552,9696771,, </pubmed> | ||
| + | |||
| + | [[Category:Protein-coding genes]] | ||
Latest revision as of 10:01, 17 April 2014
- Description: peroxiredoxin , protects the cell against organic peroxides
| Gene name | ohrA |
| Synonyms | yklA |
| Essential | no |
| Product | peroxiredoxin |
| Function | organic peroxide resistance |
| Gene expression levels in SubtiExpress: ohrA | |
| MW, pI | 14 kDa, 5.061 |
| Gene length, protein length | 423 bp, 141 aa |
| Immediate neighbours | proA, ohrR |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU13140
Phenotypes of a mutant
Database entries
- BsubCyc: BSU13140
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: osmC/ohr family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- BsubCyc: BSU13140
- Structure:
- UniProt: O34762
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
- number of protein molecules per cell (minimal medium with glucose and ammonium): 205 PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Minsun Hong, Mayuree Fuangthong, John D Helmann, Richard G Brennan
Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family.
Mol Cell: 2005, 20(1);131-41
[PubMed:16209951]
[WorldCat.org]
[DOI]
(P p)
John D Helmann, Ming Fang Winston Wu, Ahmed Gaballa, Phil A Kobel, Maud M Morshedi, Paul Fawcett, Chris Paddon
The global transcriptional response of Bacillus subtilis to peroxide stress is coordinated by three transcription factors.
J Bacteriol: 2003, 185(1);243-53
[PubMed:12486061]
[WorldCat.org]
[DOI]
(P p)
M Fuangthong, S Atichartpongkul, S Mongkolsuk, J D Helmann
OhrR is a repressor of ohrA, a key organic hydroperoxide resistance determinant in Bacillus subtilis.
J Bacteriol: 2001, 183(14);4134-41
[PubMed:11418552]
[WorldCat.org]
[DOI]
(P p)
U Völker, K K Andersen, H Antelmann, K M Devine, M Hecker
One of two osmC homologs in Bacillus subtilis is part of the sigmaB-dependent general stress regulon.
J Bacteriol: 1998, 180(16);4212-8
[PubMed:9696771]
[WorldCat.org]
[DOI]
(P p)
