Difference between revisions of "HemL"

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* '''Regulation:'''  
 
* '''Regulation:'''  
 +
** repressed in the absence of hydrogen peroxide ([[PerR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/11532148 PubMed]
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 +
** [[PerR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/11532148 PubMed]
  
 
* '''Additional information:'''  
 
* '''Additional information:'''  

Revision as of 16:58, 11 June 2009

  • Description: glutamate-1-semialdehyde aminotransferase

Gene name hemL
Synonyms hemK
Essential no
Product glutamate-1-semialdehyde aminotransferase
Function heme biosynthesis
MW, pI 46 kDa, 5.055
Gene length, protein length 1290 bp, 430 aa
Immediate neighbours spoVID, hemB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HemL context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU28120

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate (according to Swiss-Prot)
  • Protein family: HemL subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • repressed in the absence of hydrogen peroxide (PerR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed