RsbP

• Description: protein serine phosphatase, energy PP2C, dephosphorylates RsbV
  
  

Gene name	rsbP
Synonyms	yvfP
Essential	no
Product	protein serine phosphatase, energy PP2C
Function	control of SigB activity
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	45 kDa, 4.827
Gene length, protein length	1209 bp, 403 aa
Immediate neighbours	rsbQ, yvfO
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU34110

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: O-phospho-L(or D)-serine + H₂O = L(or D)-serine + phosphate (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: N-terminal PAS domain, central coiled-coil domain, C-terminal PP2C phosphatase domain

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: RsbQ-RsbP

• Localization:

Database entries

• Structure:

• Swiss prot entry: O07014

• KEGG entry: [2]

• E.C. number: 3.1.3.3

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Chet Price, Davis, USA homepage

References

Masatomo Makino, Shinpei Kondo, Tomonori Kaneko, Seiki Baba, Kunio Hirata, Takashi Kumasaka
Expression, crystallization and preliminary crystallographic analysis of the PAS domain of RsbP, a stress-response phosphatase from Bacillus subtilis.
Acta Crystallogr Sect F Struct Biol Cryst Commun: 2009, 65(Pt 6);559-61
[PubMed:19478430] [WorldCat.org] [DOI] (I p)

Margaret S Brody, Valley Stewart, Chester W Price
Bypass suppression analysis maps the signalling pathway within a multidomain protein: the RsbP energy stress phosphatase 2C from Bacillus subtilis.
Mol Microbiol: 2009, 72(5);1221-34
[PubMed:19432806] [WorldCat.org] [DOI] (I p)

1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed