Difference between revisions of "GcvPA"

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=== Basic information ===
 
=== Basic information ===
  
* '''Locus tag:'''
+
* '''Locus tag:''' BSU24560
  
 
===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
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* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P54376 P54376]
 
* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P54376 P54376]
  
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU24560 BSU24560]
+
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU24560]
  
 
* '''E.C. number:''' [http://www.expasy.org/enzyme/1.4.4.2 1.4.4.2]
 
* '''E.C. number:''' [http://www.expasy.org/enzyme/1.4.4.2 1.4.4.2]

Revision as of 13:48, 3 June 2009

  • Description: glycine decarboxylase (subunit 1)

Gene name gcvPA
Synonyms yqhJ, gcvP
Essential no
Product glycine decarboxylase (subunit 1)
Function glycine utilization
MW, pI 49 kDa, 6.947
Gene length, protein length 1344 bp, 448 aa
Immediate neighbours gcvPB, gcvT
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
GcvPA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU24560

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2 (according to Swiss-Prot)
  • Protein family: N-terminal subunit subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation: repressed by casamino acids PubMed , induced by glycine PubMed
  • Regulatory mechanism: induction requires a co-operatively acting riboswitch PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Mäder et al. (2002) Transcriptome and Proteome Analysis of Bacillus subtilis Gene Expression Modulated by Amino Acid Availability. J. Bacteriol 184: 1844288-4295 PubMed
  2. Mandal M, Lee M, Barrick JE, Weinberg Z, Emilsson GM, Ruzzo WL, Breaker RR (2004) A glycine-dependent riboswitch that uses cooperative binding to control gene expression. Science 306: 275-279. PubMed
  3. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed