Difference between revisions of "T-box"

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(Genes controlled by T-box elements)
Line 6: Line 6:
  
 
* Induction by cysteine limitation
 
* Induction by cysteine limitation
 
 
** ''[[cysE]]-[[cysS]]-[[mrnC]]-[[yacO]]-[[yacP]]''  
 
** ''[[cysE]]-[[cysS]]-[[mrnC]]-[[yacO]]-[[yacP]]''  
  
 
* Induction by tryptophan limitation
 
* Induction by tryptophan limitation
 +
** ''[[rtpA]]-[[ycbK]]''
  
** ''[[rtpA]]-[[ycbK]]''
+
* Induction by alanine limitation
 +
** ''[[alaS]]''
  
 
==Reviews on T-box regulation==
 
==Reviews on T-box regulation==
  
 
<pubmed> 19258532</pubmed>
 
<pubmed> 19258532</pubmed>

Revision as of 19:50, 27 May 2009

The T-box element is ann RNA switch that controls genes involved in amino acid metabolism.

In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid.

Genes controlled by T-box elements

  • Induction by tryptophan limitation
  • Induction by alanine limitation

Reviews on T-box regulation

Ana Gutiérrez-Preciado, Tina M Henkin, Frank J Grundy, Charles Yanofsky, Enrique Merino
Biochemical features and functional implications of the RNA-based T-box regulatory mechanism.
Microbiol Mol Biol Rev: 2009, 73(1);36-61
[PubMed:19258532] [WorldCat.org] [DOI] (I p)