Difference between revisions of "ComA"
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| − | * '''Description:''' two-component system response regulator <br/><br/> | + | * '''Description:''' two-component system response regulator, controls gene expression in response to cell density (concentration of [[ComX]]) <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| − | * '''Protein family:''' | + | * '''Protein family:''' ComA family (according to Swiss-Prot) |
* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
| Line 64: | Line 64: | ||
* '''Domains:''' | * '''Domains:''' | ||
| − | * '''Modification:''' | + | * '''Modification:''' phosphorylated by [[ComP]] |
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' | + | * '''Effectors of protein activity:''' phosphorylation activates DNA binding |
| − | * '''Interactions:''' [[RapC]]-[[ComA]] | + | * '''Interactions:''' [[RapC]]-[[ComA]], [[ComP]]-[[ComA]] |
* '''Localization:''' cytoplasm (according to Swiss-Prot) | * '''Localization:''' cytoplasm (according to Swiss-Prot) | ||
Revision as of 13:19, 23 May 2009
- Description: two-component system response regulator, controls gene expression in response to cell density (concentration of ComX)
| Gene name | comA |
| Synonyms | srfB, comAA |
| Essential | no |
| Product | two-component system response regulator |
| Function | regulation of genetic competence and quorum sensing |
| MW, pI | 23 kDa, 4.759 |
| Gene length, protein length | 642 bp, 214 aa |
| Immediate neighbours | yuxO, comP |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ComA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylated by ComP
- Cofactor(s):
- Effectors of protein activity: phosphorylation activates DNA binding
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 1U83
- Swiss prot entry: P14204
- KEGG entry: BSU31680
- E.C. number: 4.4.1.19
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
