DegS

• Description: two-component sensor kinase that controls degradative enzyme synthesis and genetic competence
  
  

Gene name	degS
Synonyms	sacU
Essential	no
Product	two-component sensor histidine kinase (EC 2.7.3.-)
Function	degradative enzyme and competence regulation
MW, pI	44 kDa, 5.988
Gene length, protein length	1155 bp, 385 aa
Immediate neighbours	degU, yvyE
Gene sequence (+200bp)	Protein sequence
Genetic context

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Ser-76 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions: DegS-DegU

• Localization:

Database entries

• Structure:

• Swiss prot entry:

• KEGG entry:

• E.C. number:

Expression and regulation

• Operon: degS-degU

• Sigma factor: SigA

• Regulation: induced in the presence of ammonium (TnrA)

• Regulatory mechanism: TnrA: repression, DegU: positive autoregulation

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Tarek Msadek, Institut Pasteur, Paris, France

References

1. Macek et al. (2007) The serine/ threonine/ tyrosine phosphoproteome of the model bacterium Bacillus subtilis. Mol. Cell. Proteomics 6: 697-707 PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed